Annals of Case Reports and Clinical Studies (ISSN: 2834-5673) | Volume 2, Issue 2 | Research Article | Open Access
Jasmine SK*
Department of Pharmaceutics, SIMS College of Pharmacy, India
*Correspondence to: Jasmine SK
Fulltext PDFOral drug delivery is the method of swallowing a pharmaceutical compound with the intention of releasing it into the gastro intestinal tract of humans and animals the purpose of Duloxetine HCL Press coated tablets were created with intention of delaying drug release to enable release in the lower region of the gastro intestinal tract. The other excipients like diet basic calcium phosphate , magnesium stearate , talc and different concentration of super disintegrates The like sodium starch , glycolate formulation of {F44 and F45} were developed to sustained the drug release from the tablet dosage form the drug release of formulations F44 and F45 was found more than 75% of drug with in 45mins in a basic medium so the combination of 60% of HPMCP and 6% sodium starch glycolate was best for the enteric coating which has given hardness, friability, weight variation, content uniformity , % drug release and disintegration and dissolution with in officially specified limits immediate release of tablet of duloxetine HCL as promising approach of enhance the drug release profile using combination of super disintegrant the results showed that from above dissolution study the formulation F44 and F45 give 98.9% drug in 60mins and also showed good hardness, thickness, friability, disintegration time, so it is selected as optimized formulation so immediate release tablet of duloxetine HCL shows better release profile as compared to other formulation . Finally, the tablet was press coated together.
Duloxetine HCL; HPMC; HPMCP; Calcium phosphate; Sodium disintegrates; Press coated tablets; Immediate release
Lakshmi Savithri S, Thangabalan B, Jasmine SK, Nandini Y, Jahnavi P, Tanuja M, et al. Formulation and Evaluation of Press Coated Tablets of Duloxetine HCl Using Hydroxy Propyl Methyl Cellulose Pthalate in Odrer to Release the Drug in the Intestine.Int Clinc Med Case Rep Jour. 2023;2(9):1-46.