Annals of Case Reports and Clinical Studies (ISSN: 2834-5673) | Volume 5, Issue 3 | Case Report | Open Access DOI
Sofia Karteri*
Sofia Karteri1*, Panagiotis Michalopoulos2, Lorenza Pecciarini3, Foteini Kalofonou4, Eirini Tarampikou1, Vasiliki Tzelepi5, Haralabos Kalofonos1
1Department of Internal Medicine, Oncology Division, Olympion Clinic, Patras, Greece
2Department of Pathology, University Hospital of Patras, Greece
3Molecular Diagnostics Unit, Department of Pathology, Ospedale San Raffaele, Milan, Italy
4Lung Unit, the Royal Marsden NHS Trust, London, UK
5Department of Pathology, Medical School, University of Patras, Greece
*Correspondence to: Sofia Karteri
Fulltext PDFGerm cell tumors (GCTs) represent the most common malignancy in men between age 20 and 39 and are typically considered to be curable malignancies. Malignant somatic transformation (MST) is a well-recognized but rare phenomenon characterized by significant heterogeneity; consequently, its pathogenesis remains poorly understood. Available data, regarding prognosis and therapeutic management are also limited, while, based on current treatment strategies, radical surgical intervention continues to represent the mainstay of therapy.
Here, we present a case of a 49-year old male with a history of GCT, stage II, initially managed with left orchiectomy (1995), adjuvant cisplatin-based chemotherapy followed by selective excision of retroperitoneal lymph nodes, who developed a relapse 25 years later with evidence of MST and presence of an adenocarcinoma subtype.
Malignant somatic transformation; Germ cell tumor; Adenocarcinoma; Retroperitoneal mass
Sofia Karteri, Panagiotis Michalopoulos, Lorenza Pecciarini, Foteini Kalofonou, Eirini Tarampikou, Vasiliki Tzelepi, et al. Germ Cell Tumor with Somatic Transformation Successfully Treated with Combined Immunotherapy: A Case Report. Ann Case Rep Clin Stud. 2026;5(3):1-8.