Annals of Case Reports and Clinical Studies (ISSN: 2834-5673) | Volume 1, Issue 1 | Case Report | Open Access
Zahed UK*
Department of Pharmacology, H.S.K College of Pharmacy, India
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Pemphigus Vulgaris is a chronic autoimmune dermatosis due to antibodies against Desminoglein 1& 3 and is characterized by bullae and erosions.[1] Diagnosis is done clinically by observing symptoms and by biopsy looking for Acantholysis under immunofluorescent assay.[2] Corticosteroids and immunosuppressants continue to be the mainstay treatment for the management of Pemphigus and Pulses of CS and an adjuvant drug is given, even though patients have benefitted, the Risk of Relapse and immune suppression is high.[3] Pulse therapy refers to the administration of intermittent supra pharmacological doses of drugs to achieve maximal effect in less time and to reduce complications of long-time drug use. Dexamethasone, Cyclophosphamide Pulse (DCP) is usually administered in treating pemphigus Vulgaris, alternatively, Dexamethasone Azathioprine pulse (AZP) can also be used if necessary, Dexamethasone Methotrexate pulse (DMP) is preferred in patients not responding to DCP/DAP.[4]
Drug; Pemphigus Vulgaris; Cyclophosphamide Pulse
Zahed UK, Ram KLM, Anirudh AM, Shalavadi MH, Madhu P.Multiple Adverse Drug Reactions in Dexamethasone Cyclophosphamide Pulse Therapy in Pemphigus Vulgaris: A Case Report.Ann Case Rep Clin Stud. 2022;1(1):1-4.