Annals of Case Reports and Clinical Studies (ISSN: 2834-5673) | Volume 3, Issue 2 | Case Report | Open Access

Navigating the Interplay: Understanding the Potential Impact of the Gut-Lung-Brain Axis on Brain Disorders

Swarup K. Chakrabarti*

Chakrabarti SK1* and Chattopadhyay D1,2

1H. P. Ghosh Research Center, Kolkata, India

2Sister Nivedita University, Kolkata, India

*Correspondence to: Swarup K. Chakrabarti 

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The "Gut-Lung-Brain" axis is a complex network involving the gastrointestinal system, respiratory system, and central nervous system, which plays a crucial role in various physiological and pathological processes. Recent research highlights the bidirectional communication along this axis is essential for the development and progression of brain disorders. Understanding the intricate interactions within the gut-lung-brain axis, including the lung-brain, gut-lung, and gut-brain axes, is key to gaining insights into neurological disorders. This understanding can foster interdisciplinary collaboration and facilitate the development of new treatments that consider the multifaceted nature of these conditions.

This comprehensive review delves into the potential contribution of the gut-lung-brain axis to the onset and progression of various brain disorders. It explores shared underlying mechanisms, such as inflammation, that mediate communication between the gut, lung, and brain, shedding light on the complex interplay of these systems. The review also highlights the significant role of the gut-lung-brain axis in shaping neurological, gastrointestinal, and respiratory processes during SARS-CoV-2 pathogenesis, emphasizing the need for a holistic approach to treating brain disorders.

This review enhances our understanding of how proteins, peptides, and metabolites interact within the interorgan communication network. It focuses on the gut-lung-brain axis as a component of this network and explains how these interactions coordinate cellular processes in health and disease. The dynamic interconnection between the gut, lung, and brain emphasizes their mutual reliance and underscores the necessity of addressing brain disorders with a holistic approach.



Chakrabarti SK, Chattopadhyay D.Navigating the Interplay: Understanding the Potential Impact of the Gut-Lung-Brain Axis on Brain Disorders.Ann Case RepClinStud.2024;3(2):1-8.