Annals of Surgery and Research | Volume 1, Issue 1 | Research Article | Open Access
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IranFulltext PDF
The treatment of refractory Gastrocutaneous Fistulas (GCFs) and Enterocutaneous Fistulas (ECFs) is extremely difficult and still is one of the most challenging clinical management. Today, there is no standardized management for them and these fistulas need complex surgery. They cause massive fluid loss which leads to electrolyte imbalance, severe dehydration, malnutrition and sepsis, and even death. This study was undertaken to investigate the effect of autologous or allogeneic platelet-rich plasma-fibrin glue (PRP-FG) on the closure of refractory GCF and ECF. Five recalcitrant GCF patients and three ECF patients were recruited. Special autologous or allogeneic PRP-FG were prepared and applied for the treatment of eight patients through an external orifice of the fistula. All fistulas closed with no complications during and after injection. Since the injection of PRP-FG through the external orifice of the fistula is safe, easy, and non-invasive, it can be repeated as long as is needed to close the fistula. PRP-FG can be used as a non-invasive method for the treatment of persistent GCF and ECF. Further research is needed to substantiate the efficacy of the injection of PRP-FG through the external orifice of the fistula for the treatment of GCF, ECF, and other types of fistulas, too.
Gastrocutaneous fistula; Enterocutaneous fistula; Platelet rich plasma; Fibrin glue
Daryoush Hamidi Alamdari. Alireza Rezapanah, Amin Dalili, Ali Jangjoo, Mohsen Aliakbarian, Hamed Golmohamadzadeh, et al.Treatment of Recalcitrant Gastrocutaneous and Enterocutaneous Fistula using Platelet-Rich Plasma -Fibrin Glue Through The External Orifice. Ann of Surg Res. 2023;2(2):1-9.