International Dentistry Journal (ISSN: 3065-4505) | Volume 4, Issue 2 | Case Report | Open Access DOI

Mechanistic Studies Based on Experimental Xerostomia Models and the Molecular Action of Cinnamaldehyde with Comparative Efficacy of Saliva Substitutes: A Recent Evidence-Based Review

Ae eun Moon^*

Hee Ja NA1 , Ae eun Moon2

1,2Department of Dental Hygiene, Honam University, An Adjunct Professor, Gwangju, Republic of Korea

^*Correspondence to: Ae eun Moon 

Abstract

Objective: This study aimed to evaluate the effects of cinnamaldehyde and the complementary role of saliva substitutes in a muscarinic receptor antagonist–induced xerostomia model.

Methods: In an animal model of xerostomia induced by 4-DAMP, cinnamaldehyde and saliva substitutes were administered individually and in combination.

Results: Cinnamaldehyde improved salivary gland tissue structure and increased saliva secretion, while saliva substitutes effectively enhanced oral moisture and alleviated symptoms.

Conclusion: Combined treatment showed complementary effects, enhancing overall therapeutic efficacy.

Keywords:

Cinnamaldehyde; Xerostomia; Muscarinic receptor antagonist; Salivary gland; Artificial saliva; Saliva secretion

Citation:

Hee Ja NA , Ae eun Moon. Mechanistic Studies Based on Experimental Xerostomia Models and the Molecular Action of Cinnamaldehyde with Comparative Efficacy of Saliva Substitutes: A Recent Evidence-Based Review. Int Dent Jour. 2025;4(2):1-5.