International Dentistry Journal (ISSN: 3065-4505) | Volume 4, Issue 4 | Case Report | Open Access
Camila Roberta Nepomuceno Atripoli*
Camila Roberta Nepomuceno Atripoli1*, Camilla Jusevicius Arouche Alves Toledo2, Sandra Regina Candido da Silva3
1Specialist in Implant Dentistry, MSc Candidate in Healthcare Management, St. Francis College, New York, USA
2Specialist in Implant Dentistry, MSc in Temporomandibular Dysfunction and Orofacial Pain, Brazil
3Specialist in Orthodontics, FAMOSP; Specialist in Implant Dentistry, Brazil
*Correspondence to: Camila Roberta Nepomuceno Atripoli
Fulltext PDFBackground: Platelet concentrates, including Platelet-Rich Plasma (PRP), Platelet-Rich Fibrin (PRF), and Leukocyte- and Platelet-Rich Fibrin (L-PRF), are autologous biomaterials used to enhance tissue regeneration in dentistry.
Objective: To review the biological mechanisms, technical protocols, and clinical applications of platelet concentrates, with emphasis on PRF and its advanced formulations.
Methods: This narrative review synthesizes current literature on PRP, PRF, A-PRF, i-PRF, and C-PRF. Special focus is given to centrifugation parameters, tube materials, and clinical outcomes in oral surgery, implantology, periodontology, and endodontics.
Results: Evidence demonstrates that PRF accelerates wound healing, promotes angiogenesis, and enhances bone regeneration. Recent innovations such as A-PRF+ and i-PRF show improved growth factor release and wider clinical versatility.
Conclusion: PRF and its derivatives are cost-effective, autologous biomaterials with broad applications in dentistry. Future research should focus on standardizing protocols and integrating PRF with regenerative technologies such as stem cells and bioprinting.
Clinical Relevance: Understanding the technical and biological aspects of PRF enhances clinicians’ ability to optimize outcomes in oral rehabilitation and regenerative procedures.
Platelet-Rich Fibrin; PRF; PRP; Regenerative dentistry; Oral surgery; Implantology; Periodontology
Camila Roberta Nepomuceno Atripoli, Camilla Jusevicius Arouche Alves Toledo, Sandra Regina Candido da Silva. Platelet Concentrates in Dentistry: Biological and Clinical Insights. Int Dent Jour. 2025;4(4):1-5.