International Journal of Gynecology and Infertility | Volume 2, Issue 1 | Review Article | Open Access DOI
Ritu Khanna*
Sipra Bagchi1, Mamta Agnihotri2, Ritu Khanna3*, Anju Mathur4, Sreelakshmy R Nair5, Sadhana Gupta6, Indu Agrawal7, Sheila Balakrishnan8, Sathi.M.S9, Archana Goel10
1Director Dr. Bagchi's IVF Centre Lucknow, India
2Fertility Specialist & Consultant Raj Hospital Kanpur, India
3Director, Fertility Specialist Khanna's Test Tube Baby Centre IVF Clinic, Varanasi, India
4Director Mangalam Hospital, Jaipur, India
5Fertility Specialist & Consultant Gynecologist Lifeline Ador, Kerala, India
6Senior Consultant (Obstetrician & Gynecology) Jeevan Jyothi Hospital, Gorakhpur, India
7Obstetrics & Gynecologists, Agrawal Nursing Home, Chandrapur, India
8Additional Professor, Govt MCH, Trivandrum, India
9Additional Professor, Govt MCH, Kottayam, India
*Correspondence to: Ritu Khanna
Fulltext PDFFemale infertility is a widespread concern affecting millions globally, with a significant portion concentrated in India alone, comprising approximately 25% of the affected population. Despite advancements in assisted reproductive technologies (ART) offering solutions to certain infertility challenges, the underlying molecular mechanisms contributing to fertility impairments remain complex and often poorly understood. Female fertility is a complex process influenced by various genetic and environmental factors. Sirtuins and Nrf2 genes have emerged as key players in maintaining reproductive health, particularly in the context of comorbid conditions such as obesity, hypothyroidism, diabetes, and polycystic ovary syndrome (PCOS). Sirtuins, a family of NAD+-dependent class 3 histone deacetylases (HDACs), were initially identified as longevity genes. However, subsequent studies have revealed their involvement in various physiological processes, including cell proliferation, apoptosis, cell cycle progression, and insulin signaling, which are crucial for female fertility. Sirtuins have been shown to activate the Nrf2 pathway, a transcription factor involved in the antioxidant response and cellular defense against oxidative stress. The interplay between these two genes has been implicated in modulating female fertility outcomes. This review aims to summarize the current understanding of the role of sirtuins and Nrf2 genes in female fertility, focusing on their individual and combined effects in the presence of comorbid conditions. We will discuss the molecular mechanisms by which these genes influence reproductive health, including the regulation of oocyte quality, embryo development, implantation, and endometrial receptivity, this review aims to provide a comprehensive understanding of their role in female fertility outcomes.
Sirtuins; Nrf2; Interplay; Diabetes; Obesity; PCOS; Hypothyroidism; Female fertility
Sipra Bagchi, Mamta Agnihotri, Ritu Khanna, Anju Mathur, Sreelakshmy R Nair, Sadhana Gupta, et al. Role Of Sirtuins, Nrf2 Genes and Their Interplay in Female Fertility Outcomes with Co Morbid Conditions Such as Obesity, Hypothyroidism, Diabetes, and PCOS: A Comprehensive Review. Int Jour Gyn Infer. 2024;2(1):1-11.