International Journal of Gynecology and Infertility | Volume 2, Issue 1 | Review Article | Open Access DOI
Jyothi Thapar*
Ruchika Garg1, Jyothi Thapar2*, Soumya Nair3, Sapna Basandani4, Sayamstuti Pattanaik5, Aswathy Kumaran6, Monu Charan Pattanayak7, Neelam Mishra8, Kunjumoideen9, Sangeeta Kumari10, Arunima Goyal11, Bidisha Roychoudhury12, Yuthika Bajpaee13, Sanjeev Behera14, Soumya Dash15
1Director and consultant, Rewati Maternity, Laparoscopy and Test Tube centre, Dehradun, Uttarakhand, India
2Consultant Gynaecologist and IVF Specialist, Kamlesh Medical Centre, Delhi, India 3Gynaecologist, Infertility Specialist, and Laparoscopic Surgeon, CIMAR, Edappal Hospital Pvt Ltd, Kerala, India
4Chief Consultant Gynaecologist, Adam Shah Memorial Hospital, Jaipur, Rajasthan, India
5Consultant Obstetrician and Gynaecologist, Laparoscopic Surgeon, and IVF Specialist, Shanti Memorial Hospital and IVF Centre, Rourkela, Odisha, India
6Consultant Reproductive Medicine and In-Charge, Aster MIMS, Kottakkal, Kerala, India
7Director, Shanti Memorial Hospital and IVF Centre, Rourkela, Orissa, India
8Scientific Director and Chief Consultant, Vansh Clinic and Test Tube Baby Centre, Lucknow, India
9Infertility Specialist, ARMC IVF Fertility Centre, Kerala, India
10Consultant Gynaecologist, Obstetrician and Infertility Specialist, Adarsh Multi-Specialty Hospital, Siwan Bihar, India
11Gynaecologist and Obstetrician, Chaitanya Hospital, Dehradun, India
12Obstetrician and Gynaecologist, IPGME&R, SSKM hospital, Kolkata, India
13Consultant Reproductive Medicine and Infertility, Regency Hospital, Kanpur, India
14Consultant in IVF and Infertility, Ahana Gynaecare & IVF, Orissa, India
15Infertility Specialist & Consultant Gynaecologist, 9m Fertility Hospital, Ankura Hospital, Bhubaneswar, Orissa, India
*Correspondence to: Jyothi Thapar
Fulltext PDFDiminished ovarian reserve (DOR) is a condition characterized by a decrease in the number and quality of oocytes, leading to reproductive decline & aneuploidies by >71%. Sirtuin a family of NAD+ dependent deacetylases have emerged as critical regulators of ovarian function and aging. This review summarizes the current understanding of Sirtuin and Nrf2 in diminished ovarian reserve, exploring their role in ovarian senescence, follicular depletion, meiotic and mitotic errors in reproductive decline. This review explores the intricate interplay between Sirtuin and nuclear factor erythroid 2-related factor 2 (Nrf2) in the context of DOR and its impact on female fertility. Sirtuin, a family of NAD+-dependent deacetylases, and Nrf2, a transcription factor involved in antioxidant response anti-inflammatory, play pivotal roles in regulating ovarian function, aging, and oxidative stress. We delve into their molecular mechanisms, including their involvement in ovarian senescence, follicular depletion, meiotic errors, and oxidative stress regulation. Furthermore, we discuss the therapeutic potential of targeting Sirtuin and Nrf2 pathways for improving reproductive outcomes in women with DOR. Understanding the Sirtuin & Nrf2 connection provides valuable insights into the pathophysiology of DOR and offers promising avenues for developing novel therapeutic interventions to enhance female fertility.
Diminished ovarian reserve; Female infertility; L-Ergothioneine; Nrf2; Nicotinamide mononucleotide; Sirtuin
Ruchika Garg, Jyothi Thapar, Soumya Nair, Sapna Basandani, Sayamstuti Pattanaik, Aswathy Kumaran, et al. The Sirtuin & Nrf2 Connection: Understanding their Impact on Diminished ovarian Reserve and Female Fertility. Int Jour Gyn Infer. 2024;2(1):1-11.