International Journal of Gynecology and Infertility (ISSN 2998-4831) (Impact Factor: 2.612) | Volume 3, Issue 1 | Original Article | Open Access
Shashank Sanagoudar*
Nagadeepti Naik1, Amol Naik1, Vipin Chandra2, Shashank Sanagoudar3*, Kshitiz Murdia3, Nitiz Murdia4, Walmik Mistari2
1Department of Reproductive Medicine, Indira IVF Hospital Ltd, Vashi
2Department of Clinical and Lab Operations, Indira IVF Hospital Ltd, Udaipur
3Department of Reproductive Medicine, Indira IVF Hospital Pvt Ltd, Udaipur
4Department of Embryology, Indira IVF Hospital Pvt Ltd, Udaipur
*Correspondence to: Shashank Sanagoudar
Fulltext PDFBackground: Thin endometrium remains a significant limiting factor in Assisted Reproductive Technology (ART), Particularly in Frozen Embryo Transfer (FET) cycles, where optimal endometrial receptivity is crucial for implantation.
Objective: To evaluate the efficacy of Tamoxifen citrate in combination with Hormone Replacement Therapy (HRT) in improving Endometrial Thickness (EMT) and reproductive outcomes in patients with refractory thin endometrium.
Methods: This retrospective study included 126 patients with EMT <7 mm despite conventional therapies. Patients received Tamoxifen (40 mg/day, Days 2–6) along with estradiol valerate. EMT before and after treatment and biochemical pregnancy rates were analyzed.
Results: A statistically significant increase in EMT was observed (6.51 ± 0.75 mm vs 7.64 ± 0.59 mm; p < 0.001). The biochemical pregnancy rate was 69%.
Conclusion: Tamoxifen in combination with HRT significantly enhances endometrial thickness and improves reproductive outcomes in refractory thin endometrium.
Naik N, Naik A, Chandra V, Sanagoudar S, Murdia K, Murdia N, et al. Use of Tamoxifen Citrate with Hormone Replacement Therapy in Frozen Embryo Transfer Cycles for Thin Endometrium: A Retrospective Study. Int Jour Gyn Infer. 2026;3(1):1-7.