Salient Journal of Cardiology (ISSN 2994-774X) | Volume 5, Issue 5 | Review Article | Open Access

Drug-Induced Long QT Syndrome and Torsades de Pointes: A Cardiological Review of Mechanisms, Risk Stratification, and Clinical Management

Muhammad Sheraz^*

Muhammad Salman Abu Bakar Janjua1, Hafsa Khizar2, Marwa Tufail2, Muhammad Tashfeen Chishti2, Muhammad Syed Ali Akbar Rizvi2, Muhammad Sheraz3*, Ujala Ahmed4, Fiza Fazeela5

1Bolan Medical College, Quetta

2Multan Medical & Dental College, Multan

3Nishtar Medical University, Multan

4Hamdard University Hospital, Karachi

5Chandka Medical College, Larkana

^*Correspondence to: Muhammad Sheraz 

Abstract

Drug-induced long QT syndrome (diLQTS) is an acquired cardiac electrophysiological disorder characterized by prolongation of the corrected QT (QTc) interval on electrocardiography (ECG), which predisposes patients to torsades de pointes (TdP), a polymorphic ventricular tachyarrhythmia that can degenerate into ventricular fibrillation and cause sudden cardiac death.[1–3] It is among the most clinically significant yet preventable causes of malignant arrhythmias in both inpatient and outpatient settings.[4] The condition is particularly relevant in modern medicine due to widespread use of QT-prolonging drugs across cardiology, psychiatry, infectious diseases, and oncology. This review discusses the molecular mechanisms, pharmacological triggers, clinical risk stratification, and evidence-based management strategies for diLQTS and TdP.

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Citation:

Muhammad Salman Abu Bakar Janjua, Hafsa Khizar, Marwa Tufail, Muhammad Tashfeen Chishti, Muhammad Syed Ali Akbar Rizvi, Muhammad Sheraz, Ujala Ahmed, Fiza Fazeela. Drug-Induced Long QT Syndrome and Torsades de Pointes: A Cardiological Review of Mechanisms, Risk Stratification, and Clinical Management. Sali Jour Cardi. 2023;5(5):1-7.