Annals of Medicine Research and Public Health (ISSN: 2995-5955) | Volume 4, Issue 1 | Case Report | Open Access DOI

Aztreonam–Avibactam as Salvage Therapy in Carbapenem Resistant Klebsiella Pneumoniae Infection with Renal Failure and Neurological Risk

Balasubrahmanyam Chandrabhatla*

Balasubrahmanyam Chandrabhatla1*, Manisha C2, Palepu B Gopal3, Bharath Kumar Pamulapati4*, Amitha Gade5

1Senior Consultant Critical Care Physician , Citizens Specialty Hospitals, Nallagandla, Hyderabad, India

2Critical care medicine, Department of critical care medicine, Citizen’s specialty hospitals Nallagandla, Hyderabad, Telangana, India

3Head of the Department, Department of critical care medicine, Citizen’s specialty hospitals Nallagandla, Hyderabad, Telangana, India

4Head of the Department, Department of critical care medicine, KIMS sikhara hospitals Guntur, Andhra Pradesh, India

5Head of the Department, Department of Microbiology, AMPATH Nallagandla, Hyderabad, Telangana, India

*Correspondence to: Balasubrahmanyam Chandrabhatla 

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Abstract

We describe the first documented use of Aztreonam–Avibactam under compassionate use for treatment of Metallo-β-lactamase–producing Klebsiella pneumoniae infection in our country. The patient achieved full clinical and microbiological cure without recurrence, and no adverse events occurred. This case underscores the therapeutic potential of Aztreonam–Avibactam in managing multidrug-resistant Gram-negative infections with limited treatment options.

Keywords:

Carbapenem Resistant-Klebsiella pneumonia; Aztreonam-avibactam; MBL-Klebsiella; XDR- Klebsiella

Citation:

Balasubrahmanyam Chandrabhatla, Manisha C, Palepu B Gopal, Bharath Kumar Pamulapati, Amitha Gade. Aztreonam–Avibactam as Salvage Therapy in Carbapenem Resistant Klebsiella Pneumoniae Infection with Renal Failure and Neurological Risk. Ann Med Res Pub Health. 2025;4(1):1-8.