Annals of Medicine Research and Public Health (ISSN: 2995-5955) | Volume 3, Issue 1 | Case Series | Open Access DOI
Abdullah Aleem, MD*
Abdullah Aleem, MD1*, Blake Purtle, MD1, Keith Garrison, MD1, Suhair Al Salihi, MD1, Andrew Dupont, MD1
1Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA
*Correspondence to: Abdullah Aleem, MD
Fulltext PDFIschemic colitis (IC) occurs when blood flow to the colon is compromised, typically appearing at the splenic flexure or rectosigmoid junction, known as ‘watershed’ areas. Various pharmacological agents, including nonsteroidal anti-inflammatory drugs (NSAIDs), oral contraceptives, phentermine, antipsychotics, and certain antibiotics (notably penicillin derivatives) have been implicated in IC pathogenesis. Although fluoroquinolones have been associated with pseudomembranous colitis in Clostridioides difficile infection (CDI), culture-negative colitis following fluoroquinolones is extremely rare. We report two cases of ciprofloxacin-induced IC. The first case was that of a 38-year-old woman who developed symptoms on day 4 of ciprofloxacin use. The second case involved a 68-year-old woman who developed symptoms one week after completing a 10-day course of ciprofloxacin. Colonoscopy and histopathology confirmed the presence of IC in both cases.
Ischemic colitis; Fluoroquinolones; Antibiotics; Infectious colitis; Hemorrhagic colitis; Klebsiella oxytoca; Clostridioides difficile
Abdullah Aleem, Blake Purtle, Keith Garrison, Suhair Al Salihi, Andrew Dupont. Fluoroquinolone Induced Ischemic Colitis: A Case Series and Review of Literature. Ann Med Res Pub Health. 2024;3(1):1-7.