Annals of Medicine Research and Public Health (ISSN: 2995-5955) | Volume 3, Issue 1 | Case Report | Open Access

Utilization of Cannabis for Chronic Pain Disorders: National Inpatient Sample (NIS) Database Analysis

Supriya D. Mahajan*

Neel Patel1, Neil U. Parikh2, Ravi kumar Aalinkeel2, Tracey A. Ignatowski3, and Supriya D. Mahajan2*

1Icahn School of Medicine at Mount Sinai, USA

2Department of Medicine, Division of Allergy, Immunology & Rheumatology, SUNY University at Buffalo, USA

3Department of Pathology and Anatomical Sciences, SUNY University at Buffalo, School of Medicine & Biomedical Sciences, USA

*Correspondence to: Supriya D. Mahajan 

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Background: Over the last decade, cannabis (marijuana) use has increased for a various medical condition. However, there is very little data on marijuana use for chronic pain disorders and associated predictors of its use.

Aim: To evaluate national trends of marijuana utilization for various pain disorders and epidemiological characteristics. Method: We queried sample using ICD 9 CM code from a National Inpatient Dataset (NIS) from 2008 to 2014. We included patients with ICD-9 codes 304.30-304.32, which were defined as CBD Use-related Disorder (CUD), and those with ICD-9 codes 305.20-305.22, defined as a Non-CUD group. All comparisons were performed between the CUD vs. Non-CUD groups. Categorical variables and continuous variables were assessed by the Rao Scott χ2 test and Wilcoxon rank-sum, respectively.

Result: Out of 17,675,000 CUD patients, the most common use was to treat back pain disorders (84.8%), followed by chronic pain syndrome (10.09%), neoplasm pain (3.25%), and post-operative pain (0.28%). The utilization was more prevalent among the males than females (61.8% vs. 38.2%; p<0.001). The median Length of Stay (LOS) for the CUD patients was higher compared to the MNU patients (3.19 days vs. 2.83 days; p<0.001). Compared to Non-CUD, CUD had lower odds of CHF (OR: 0.84, CI: 0.79 - 0.89; p<0.001) and depression (OR: 0.95, CI: 0.92-0.98, P=0.001) and higher odds of alcohol abuse (OR: 1.42, CI:1.38-1.47; P<0.001) and anxiety disorder (OR:1.11, CI:1.07-1.14; P<0.001).

Conclusion: Our analysis revealed a substantial prevalence of marijuana use among patients with chronic pain disorders. Back pain emerges as the predominant indication for CBD usage, with the 41-60 age group being the most prevalent demographic. While CUD patients exhibit a longer hospital stay and varied outcomes for certain medical conditions, including both positive and negative associations, our study underscores the urgent need for more extensive and standardized research.


THC: Delta-9-tetrahydrocannabinol; CBD: Cannabidiol; Cannabis (Marijuana); Chronic pain disorder; NIS: National (Nationwide) Inpatient Sample database


Neel Patel, Neil U. Parikh, Ravi kumar Aalinkeel, Tracey A. Ignatowski, Supriya D. Mahajan. Utilization of Cannabis for Chronic Pain Disorders: National Inpatient Sample (NIS) Database Analysis. Ann Med Res Pub Health. 2024;3(1):1-13.