International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 7 | Case Report | Open Access

A Case of Carcinoma with Apocrine Differentiation of the Breast; Cytopathological Analysis and A Consideration to The Pathogenesis

Hideki Mori^*

1Department of Endocrine Surgery, Ogaki Tokushukai Hospital, Japan

2Clinical Laboratory Department, Ogaki Tokushukai Hospital, Japan

3Department of Pathology, Asahi University Hospital, Japan

4Department of Diagnostic Hospital, Ogaki Tokushukai Hospital, Ogaki, Gifu, Japan

^*Correspondence to: Hideki Mori 

Abstract

We report a rare case of invasive carcinoma with apocrine differentiation (apocrine carcinoma) in 86-year-old female presenting a breast lump. The tumor had a characteristic steroid receptor profile being estrogen (ER)-negative, progesterone (PR)-negative and androgen (AR)-positive, and classical apocrine morphology in at least 90% of the tumor. Cytopathological analysis of this neoplasm using fine needle aspiration cytology and core needle biopsy clarified characteristic morphology of the apocrine carcinoma, and immunohistochemical profiles made clear differential diagnosis of the apocrine carcinoma from resemble lesions with eosinophilic granular cells such as carcinoma with oncocytic pattern, granular cell tumors and histiocytic proliferation.

Pathogenesis of carcinoma with apocrine differentiation is unknown. Occurrence of apocrine cells in the neoplasm of the breast has been regarded as through metaplastic processes. In this case, the tumor was constituted by uniform cells with apocrine morphology. Importantly, co-existence of other tumor types or lesions like apocrine ductal carcinoma in situ (DCIS) was not present. The evidence implies that histogenesis of the apocrine carcinoma in the present case was through the rout directly developed from some native cells originated in fetal breast tissue or through the rout directly transformed cells from some normal adult cells in the mammary gland.

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Citation:

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