International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 12 | Case Report | Open Access DOI
Veerasivabalan S*
Veerasivabalan S1*, Sukanya N2, Kiruthika J3, Kalpana Ramanathan4, Chandrasekar S5
1Post Graduate of General Medicine, Department of General Medicine, Government Stanley Medical College and Hospital, Chennai, India
2Senior Assistant Professor of General Medicine, Department of General Medicine, Government Stanley Medical College and Hospital, Chennai, India
3Assistant Professor of General Medicine, Department of General Medicine, Government Stanley Medical College and Hospital, Chennai, India
4Professor, Department of General Medicine, Government Stanley Medical College and Hospital, Chennai, India
5Professor and Head, Department of General Medicine, Government Stanley Medical College and Hospital, Chennai, India
*Correspondence to: Veerasivabalan S
Fulltext PDFWilson disease is an autosomal recessive disorder characterized by abnormal copper homeostasis resulting in the accumulation of copper in various organs in the body. Wilson is a multisystem disease with predominant liver damage and neuropsychiatric manifestations. The endocrine abnormalities encountered in association with Wilson disease are rare. We present a case of a 33-year-old male, a known case of Wilson disease who presented with extreme prostration and anorexia. He had refractory hypotension for which a comprehensive laboratory test and hormonal panel was done, which suggested secondary adrenal insufficiency. Magnetic resonance imaging of the Sella with contrast was done which showed no abnormality in the pituitary. The absence of structural pathology in the neuroimaging of the pituitary in the presence of hypopituitarism could be attributed to the copper mediated oxidative neuronal injury in the hypophysis. It is plausible that copper chelation and hormone replacement might improve pituitary function in Wilson disease. This paper aims to highlight the endocrine manifestations associated with Wilson disease.
Wilson disease; Adrenal insufficiency; Hypopituitarism; KF ring; Metabolic bone disease; Central hypothyroidism; Fanconi syndrome
Veerasivabalan S, Sukanya N, Kiruthika J, Kalpana Ramanathan, Chandrasekar S. A Case Report of Secondary Adrenal Insufficiency in Wilson Disease. Int Clinc Med Case Rep Jour. 2024;3(12):1-7.