International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 7 | Research Article | Open Access DOI
José Victor da Nóbrega Borges*
José Victor da Nóbrega Borges1*, Samira Abdel Correia Leila2, Manuella Guedes da Nóbrega Machado3
1University of Sao Paulo Medical School, Heart Institute (Sao Paulo - Brazil)
2Hospital Israelita Albert Einstein (Sao Paulo - Brazil)
3Clínica Central de Diagnóstico (Vilhena - Brazil)
*Correspondence to: José Victor da Nóbrega Borges
Fulltext PDFBackground: Coronary artery bypass grafting (CABG) can be performed using on-pump or off-pump techniques. The optimal approach remains debated.
Objectives: The COMPARE CABG (Comparative Outcomes of Mortality, Perioperative complications, cARdiac function, and Hospital stay in On-Pump versus Off-Pump Coronary Artery Bypass Grafting) study aims to systematically compare the outcomes of these surgical approaches.
Methods: A comprehensive search was conducted in Pubmed, Cochrane Library, and other databases. Studies with a sample size > 4000 were included. Outcomes analyzed included mortality, complications, cardiac function, and hospital stay.
Results: Meta-analysis of 5 studies with 58,232 patients showed that off-pump CABG was associated with a slightly lower complication rate: 15% for on-pump CABG and 13.5% for off-pump CABG with a pooled effect size of 0.90 (95% CI: 0.85-0.95). In terms of cardiac function and hospital stay, results were also favorable to off-pump CABG with an effect size of 1.12 (95% CI: 1.05-1.19) and 1.15 (95% CI: 1.10-1.20), respectively. The pooled mortality rate was 2.5% for on-pump and 2.4% for off-pump CABG, with an effect size of 1.05 (95% CI: 0.98-1.12), indicating no significant difference between the groups.
Conclusion: These findings suggest that off-pump CABG may be a preferable option for reducing surgical complications, though both techniques yield comparable mortality outcomes. Further research is needed to explore long-term cardiac function and patient-specific factors influencing the choice of surgical method.
José Victor da Nóbrega Borges, Samira Abdel Correia Leila, Manuella Guedes da Nóbrega Machado. A Meta-Analysis of Comparative Outcomes in On-Pump vs. Off-Pump Coronary Artery Bypass Grafting. Int Clinc Med Case Rep Jour. 2024;3(7):1-14.