International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 1, Issue 11 | Review Article | Open Access

A Recent Development in Sepsis Management: A Literature Review

Satyam Singh*

Department of Internal Medicine, LLR Hospital, Kanpur, India

*Correspondence to: Satyam Singh 

Fulltext PDF


Sepsis is when the host's abnormal immune response leads to multi-organ failure. It is also one of the most common causes of death worldwide. The pathogenesis of sepsis is very complex; in sepsis, the body's first response to the external antigen is phagocytosis by the macrophage, which activates the immune system, resulting in a cytokine storm due to immune dysfunction. Mitochondrial damage is seen, which causes decreased ATP production, and an increase in free radical production leads to oxidative stress and alters cellular metabolism. These reactions eventually result in cell death, endoplasmic reticulum stress, and blood coagulability changes. Management involves early diagnosis of sepsis, initial empirical treatment with broad-spectrum antibiotics, and fluid resuscitation to maintain the mean arterial blood pressure necessary for restoring normal tissue perfusion with the usage of inotropic agents when initial fluid resuscitation is unable to meet the tissue requirements. This review aims to provide information about the updates in managing sepsis.


Continuous Renal Replacement Therapy (CRRT); Intermittent Hemodialysis (IHD); Sequential Organ Failure Assessment (SOFA); Systemic Inflammatory Response Syndrome (SIRS); Sepsis


Sanathan Aiyadurai, Enoh Nguty Nkeng, Etaluka Blanche Mungu, Zainab Omar, Vivian C Chukwuedozie, Abimbola O Ajibowo, et al.A Recent Development in Sepsis Management: A Literature Review.Int Clinc Med Case Rep Jour. 2022;1(11):1-17.