International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 11 | Research Article | Open Access
Wenli Chen*
Department of General Surgery, The Afffliated Bozhou Hospital of Anhui Medical University, China
*Correspondence to: Wenli Chen
Fulltext PDFBackground: Appendicitis is an acute inflammatory disorder involving immune dysregulation, and Activation-Induced Cytidine Deaminase (AID)—a key immune mediator—regulates B-cell function and inflammatory responses.
Objective: To synthesize basic experimental evidence on AID’s role in appendicitis and explore its nursing relevance.
Methods: Retrospective analysis of PubMed (2019–2024) using keywords “Appendicitis[MeSH] AND Activation-Induced Cytidine Deaminase[MeSH] AND Basic Research[Filter]”. Eligible studies were animal/cell models focusing on AID in appendicitis.
Results: Eight studies were included. AID expression was upregulated in appendiceal tissues of animal models (mouse/rat) and LPS-stimulated immune cells, correlating with reduced pro-inflammatory cytokines (TNF-α, IL-6) and enhanced anti-inflammatory responses (IL-10). AID activation alleviated appendiceal damage. Conclusion: AID modulates immune-inflammatory processes in appendicitis, providing a basis for nursing strategies in infection control and inflammation management.
Appendicitis; Inflammatory disorder; Immune mediator; Immune cells
Chen W. Activation-Induced Cytidine Deaminase (AID) in Appendicitis. 2025;4(11):1-5.