International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 6 | Review Article | Open Access DOI
Bushra Firdous Shaik*
Bushra Firdous Shaik1*, Simhachalam Gurugubelli2, Sai Kiran Attluri3, Swetha Yadav Musty4
1Department of Internal Medicine, Piedmont Macon Hospital, Macon Georgia, USA
2Clinical Assistant Professor IU School of Medicine, Fortwayne, Indiana, USA
3MBBS AIIMS Mangalagiri, India
4Department of Internal Medicine, Piedmont Macon Hospital, Macon Georgia, USA
*Correspondence to: Bushra Firdous Shaik
Fulltext PDFAmyloidosis is a systemic disease characterized by the abnormal deposition of amyloid proteins in various tissues and organs, leading to disrupted organ function. Amyloids are misfolded proteins that aggregate into fibrils, which accumulate in extracellular spaces and tissues. With the most frequent type of amyloidosis being AL amyloidosis in the United States and AA amyloidosis in developing countries,[1] a relatively rare form (ALECT2) protein amyloidosis was discovered by Benson et al.[2] Based on the case reports published, data shows the disease appears to be more prevalent in regions such as Latin America, especially in Mexico.[3] There are cases reported from Northern India.[4] New studies show (ALECT2) protein amyloidosis is considered the third most common amyloidosis involving the kidneys in the United States, accounting for 2.5%-2.7% of renal amyloidosis cases. Worldwide, ALECT2 was found to be the second most common form of renal amyloidosis among Egyptians and was also reported among Pakistani, Sudanese, and Chinese populations.[5,6] In North America, approximately 90% of the reported cases of ALECT2 amyloidosis occur in older Hispanic adults of Mexican origin.[7] Studies show that ALECT2 amyloidosis is more commonly diagnosed in older individuals, especially those with renal transplants.[8] Although renal involvement is the most frequently reported, a case with hepatic involvement is reported from hispanic origin.[9]
Bushra Firdous Shaik, Simhachalam Gurugubelli, Sai Kiran Attluri, Swetha Yadav Musty. ALECT2 Amyloidosis Review. Int Clinc Med Case Rep Jour. 2025;4(6):1-5.