International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 4 | Case Report | Open Access DOI
Jerome H Check*
Donna Summers BS 1, Jerome H Check MD, Ph.D.1,2*
1Cooper Institute for Reproductive Hormonal Disorders, P.C. Mt. Laurel, NJ
2Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ
*Correspondence to: Jerome H Check
Fulltext PDFThis case report describes a couple who achieved two live births after seven failed in vitro fertilization cycles by the addition of artificial oocyte activation (AOA) to the intracytoplasmic sperm injection (ICSI) used in their normal course of treatment. Their fertilization history was within normal limits, but implantation failed to occur after several fresh embryo transfers as well as preimplantation genetic tested (PGT) frozen embryo transfers. The addition of AOA may have augmented the patient’s typical oocyte activation, leading to more robust embryo development and thus implantation. The safety and efficacy of the technique is reasonably established and should be considered an option before recommending donor gametes to patients in cases of repeated implantation failures.
Artificial oocyte activation, Calcium ionophore, Refractory infertility, Intracytoplasmic sperm injection, In vitro fertilization-embryo transfer
Donna Summers BS, Jerome H Check, MD, Ph.D.. Artificial Oocyte Activation with Calcium Ionophore May Improve Implantation of Potential in Recalcitrant Infertility. Int Clinc Med Case Rep Jour. 2025;4(4):1-9.