International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 1 | Case Report | Open Access DOI
Neelam Sangwan*
Sheetal Nara1, Neha Saini1, Muktesh Chandra2, Sonam Kumari1, Nisha Yadav1,3, Neelam Sangwan1*
1Department of Biochemistry, Central University of Haryana, Mahendergarh, India
2Department of Bioinformatics, Marwadi University, Rajkot, Gujarat, India
3Department of Zoology, Deen Dayal Upadhyaya College, University of Delhi, India
*Correspondence to: Neelam Sangwan
Fulltext PDFThe appearance of coronaviruses, particularly SARS-CoV-2, had highlighted the significant role of the innate immune system in determining the severity and outcome of viral infections. As the first line of defence, the immune response relies on pattern recognition receptors, such as Toll-like receptors and the NLRP3 inflammasome, to initiate pro-inflammatory responses aimed at combating viral threats. However, an excessive or dysregulated immune response, including hypercytokinemia, can lead to tissue damage and exacerbate disease severity. Recent studies suggest that nutritional immunomodulation can influence the effectiveness of the immune system and potentially mitigate the impact of coronavirus infections. Nutrients like vitamins D, C, and zinc have been shown to modulate immune functions by enhancing immune activity, promoting anti-inflammatory responses, and improving viral clearance. These nutritional interventions may improve the body's response towards viral infections, reduce inflammation, and prevent excessive immune activation. This review explores the intricate relationship between coronaviruses, innate immunity, and nutritional immunomodulation, emphasizing the potential of targeted nutritional strategies to support immune function and manage the impact of coronavirus infections. Understanding the molecular mechanisms behind these interactions may provide new insights for therapeutic interventions in viral diseases like COVID-19.
COVID-19, Vitamin D, Vitamin C, Zinc, Immunity
Sheetal Nara, Neha Saini, Muktesh Chandra, Sonam Kumari, Nisha Yadav, Neelam Sangwan. Association of Innate Immunity and Nutritional Immunomodulation under Coronavirus Infection. Int Clinc Med Case Rep Jour. 2025;4(1):1-9.