International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 5, Issue 3 | Research Article | Open Access DOI

Bilayer Tablets: Design, Technologies and Therapeutic Applications

Abhishek Raj^*

Abhishek Raj1* and Dr.Amit Sharma2

1PhD Scholar (Department of Pharmacy) Faculty of Medical, Paramedical and Allied Health Sciences, Jagannath University, Jaipur, Rajasthan, India

2Dean (Medical, Paramedical and Allied Health Sciences) and HOD (Pharmacy), Jagannath University, Jaipur, Rajasthan, India

^*Correspondence to: Abhishek Raj 

Abstract

Bilayer tablets are advanced oral solid dosage forms composed of two distinct layers, each formulated to achieve specific drug release profiles or to physically separate incompatible active pharmaceutical ingredients (APIs). These systems enable the combination of immediate-release (IR) and sustained-release (SR) components within a single unit, improving therapeutic efficacy, patient compliance, and pharmacokinetic control. This article reviews the principles, formulation strategies, manufacturing technologies, evaluation parameters, and recent advances in bilayer tablet systems, highlighting their growing importance in modern drug delivery.

Keywords:

Bilayer tablets; Sustained Release; SRDF; Matrix System; Modified Release; Extended Release

Citation:

Abhishek Raj, Dr.Amit Sharma. Bilayer Tablets: Design, Technologies and Therapeutic Applications. Int Clinc Med Case Rep Jour. 2026;5(3):1-7.