International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 11 | Review Article | Open Access
Priya Kumari*
Priya Kumari*, Somya Gupta, Vaishnavi Raj, Shanu Kumari, Ahmed Mustafa Bakht, Shashank Srivastav, Danish Iqbal, Abhishek Kumar
BDS Intern, Sarjug Dental College and Hospital, Darbhanga, Bihar
*Correspondence to: Priya Kumari
Fulltext PDFUnder natural environmental settings or in the human body, the majority of microorganisms exist in complex polymicrobial biofilms adhered to abiotic and biotic surfaces. These microorganisms exhibit symbiotic, mutualistic, synergistic, or antagonistic relationships with other species during biofilm colonization and development. These polymicrobial interactions are heterogeneous, complex, and hard to control, thereby often yielding worse outcomes than monospecies infections.
Concerning fungi, Candida spp., in particular, Candida albicans is often detected with various bacterial species in oral biofilms. These Candida-bacterial interactions may induce the transition of C. albicans from commensal to pathobiont or dysbiotic organism. Consequently, Candida–bacterial interactions are largely associated with various oral diseases, including denture stomatitis, dental caries, periodontitis, peri-implantitis, endodontic infections, and oral cancer. Given the severity of oral diseases caused by cross-kingdom consortia that develop hard-to-remove and highly drug-resistant biofilms, fundamental research is warranted to strategically develop cost-effective and safe therapies to prevent and treat cross-kingdom interactions and subsequent biofilm development. While studies have shed some light, targeting fungal-involved polymicrobial biofilms has been limited. This mini-review outlines the key features of Candida-bacterial interactions and their impact on various oral diseases. In addition, current knowledge on therapeutic strategies to target Candida-bacterial polymicrobial biofilms is discussed.
Candida albicans, Bacteria, Cross-kingdom biofilm, Oral diseases, Therapeutics
Priya Kumari, Somya Gupta, Vaishnavi Raj, Shanu Kumari, Ahmed Mustafa Bakht, Shashank Srivastav,, et al. Candidiasis and Bacterial Interactions : An unexplored Aspect. Int Clinc Med Case Rep Jour. 2025;4(11):1-7.