International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 2, Issue 12 | Research Article | Open Access
Fadoua Bouguerra*
Radiation-Oncology Department, Salah AzaizInstitute of oncology, Tunis-Tunisia
*Correspondence to: Fadoua Bouguerra
Fulltext PDFBackground and Aim: Breast cancer is the second most common cause of brain metastases after lung cancer. However, the incidence of cerebral metastases from breast cancer has increased during the last years.
The purpose of this study is to determine the prognosticvalue of chemotherapy after whole-brain radiotherapyfor patients with brain metastases from breast cancer.
Methods: We analyzed retrospectively 63 records of patients diagnosed with brain metastases from breast cancer and treated in the radiotherapy department at the Salah Azaiz Institute of oncology over a 5-year period between 2007 and 2011. All patients received whole-brain radiotherapy. Only 4 patients had surgical resection of the metastases before radiotherapy and 36,5% of patients received systemic treatment after irradiation.
Results: Overall survival was 19% at 1-year and median survival was 4,5 months. Univariate analysis indicated that systemic treatment after irradiation was correlated significantly with longer survival. (p=0,046).
Conclusion: Determining prognostic factors might help optimize individual treatment for metastatic breast cancer.The results of our study suggest that chemotherapy is more effective on brain metastases after irradiation. This can be explained by the fragilization of the blood-brain barrier by radiation and subsequently a better passage of cytotoxic agents.
Key words: Brain metastases, Metastatic breast cancer, Radiotherapy, Chemotherapy, Palliative care.
Brain metastases; Metastatic breast cancer; Radiotherapy; Chemotherapy; Palliative care
Fadoua Bouguerra, Semia Zarraa, Wael Kaabia, Hela Hammami, Mohamed Souissi, Emna Boudhina, et al. Chemotherapy after Whole-Brain Radiotherapy: A Prognostic Factor for Metastatic Breast Cancer. Int Clinc Med Case Rep Jour. 2023;2(12):1-10.