International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 4 | Case Report | Open Access DOI
Yogesh S*
Varuna Priya C¹, Hariharan C², Yogesh S3*, Gokulakrishnan H3, Selvakrishna R1, Suriya Prakash S1, Venkat Bhabu G1, Lakshmi Murugesan4, Nithila Sivakumar4, Lakshiya Ramamoorthy4
1Post graduate, Institute of Internal Medicine, Madras Medical College, Chennai, India
2Director and Professor, Institute of Internal Medicine, Madras Medical College, Chennai, India
3Assistant Professor, Institute of Internal Medicine, Madras Medical College, Chennai, India
4MBBS (Graduate), Institute of Internal Medicine, Madras Medical College, Chennai, India
Fulltext PDFPure red cell aplasia (PRCA) is a bone marrow failure disorder where only the red cell lineage is getting affected. It manifests as normocytic, normochromic anemia or macrocytic anemia with reticulocytopenia with absent or extremely infrequent erythroid precursors in the bone marrow. We have both congenital and acquired causes. Human immunodeficiency virus (HIV) comes under a roof of family called Human Retroviruses (retroviridae). Globally, there is a burden of approximately 39 million people affected by HIV, with around 3.14 million residing in India. This accounts for approximately 0.7% of individuals aged between 15 and 49 years worldwide living with HIV. Within this population, approximately 0.6 million HIV-related deaths occur. HIV induces an immunocompromised state, serving as fertile ground for infections that can be treated and prevented by appropriate ART regimens. The most common hematological manifestation in HIV infection is anemia, which increases mortality and morbidity in these patients. Therefore, identifying a correctable cause is crucial when treating People Living with HIV (PLHIV). One such treatable cause is anemia due to pure red cell aplasia caused by Chronic Parvovirus B19 infection. Treatment options include steroids, appropriate ART, and Intravenous Immunoglobulin (IVIG). Here, we discuss the case of an 18-year-old boy, a PLHIV patient who presented to us with refractory anemia and its successful treatment with Intravenous Immunoglobulin.
Human immunodeficiency virus (HIV); Pure red cell aplasia (PRCA)
Varuna Priya C, Hariharan C, Yogesh S, Gokulakrishnan H, Selvakrishna R, Suriya Prakash S, et al. Chronic Parvovirus B19 Infection and Pure Red Cell Aplasia In A PLHIV Patient. Int ClincMed Case Rep Jour. 2024;3(4):1-8.