International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 2 | Case Report | Open Access DOI
Carly Hubers*
Meumbur P Kpughur-Tule1, Carly M. Hubers2*, Saba Asif1, Ngumimi P Kpughur-Tule1, Kendall Conway2, Alexander M. Satei3
1Internal Medicine, Trinity Health Oakland, Pontiac, USA
2Internal Medicine, Wayne State University School of Medicine, Detroit , USA
3Diagnostic Radiology, Wayne State University, Detroit, USA
*Correspondence to: Carly Hubers
Fulltext PDFSchistosomiasis, a parasitic infection endemic to sub-Saharan Africa, is an uncommon but significant cause of liver disease in developed countries, particularly when compounded by additional hepatic insults. This case report describes a 71-year-old male with severe liver cirrhosis resulting from multifactorial etiologies, including chronic schistosomiasis, viral hepatitis, possible autoimmune hepatitis, and monoclonal gammopathy of undetermined significance (MGUS). Despite initial praziquantel therapy, incomplete treatment allowed for ongoing granulomatous inflammation and fibrosis. The patient’s clinical presentation included portal hypertension, recurrent variceal bleeding, and profound anemia. This case highlights the complex interplay of multiple hepatic insults, the critical need for adherence to antiparasitic therapy, and the challenges of managing overlapping liver pathologies. Increased awareness of schistosomiasis and its role in liver disease is vital for timely diagnosis and intervention, particularly in patients from endemic regions.
Parasite infection; Granulomatous inflammation; Viral hepatitis; Autoimmune hepatitis; schistosomiasis
Meumbur P Kpughur-Tule, Carly M. Hubers, Saba Asif, Ngumimi P Kpughur-Tule, Kendall Conway, Alexander M Satei. Compounded Hepatic Insults: The Convergence of Schistosomiasis, Prior Hepatitis B Exposure, and Autoimmune Hepatitis. Int Clinc Med Case Rep Jour. 2025;4(2):1-3.