International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 11 | Conference Paper | Open Access DOI
Tathagata Roy Chowdhury*
Suvarthy Dey1, Tathagata Roy Chowdhury2*
1MBBS, MPH (Occupation and environmental health; major: Occupational health and safety); Msc in biomedicine, India
2Assistant Professor, Department of Computer Science and Engineering, Techno Engineering College Banipur, India
*Correspondence to: Tathagata Roy Chowdhury
Fulltext PDFFluvastatin is a drug of the statin group which have been widely used for treatment of hypercholesterolemia. Fluvastatin has shown to induce lower locomotion and general activity in flies. The dose response curve however has not been established yet. Accordingly, we aimed to examine different concentrations of Fluvastatin in flies to establish the dose response curve. This is very important to obtain the dose-curve response. Here we tried to identify dose response curve by using fruit fly (Drosophila melanogaster) activity monitoring system (DAMS). We have used CSORC variant of virgin males fruit fly and divided in three groups among which one group was control group and two different concentrations of Fluvastatin treated other two groups. To identify differentiation between two different concentrations of this experiment was done by using DAMS since it is not clearly understood at which concentration the Fluvastatin has the highest effect, i.e., make the activity of the flies lower. We have done DAMS for 5 hours. 5hours later we have done DAMS analysis and found that, the control group flies were more active than the flies’ treated with Fluvastatin. The result does not show any difference in effect between the two concentrations. At the same time, we also got contradictory results regarding sleep duration. The control group flies had lower sleep duration than the other two groups of flies which Fluvastatin treated. This finding is completely opposite than the findings of another research.
Fluvastatin; Drosophila melanogaster; Statin-induced myopathy; Dose-response curve; Locomotion; Sleep duration; HMG-CoA reductase; Muscle activity; Drosophila Activity Monitoring System (DAMS)[ Cholesterol
Suvarthy Dey, Tathagata Roy Chowdhury. Dose-Dependent Effects of Fluvastatin on Locomotion, Muscle Function, and Sleep Patterns in Drosophila Melanogaster. Int Clinc Med Case Rep Jour. 2024;3(11):1-11.