International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 5 | Research Article | Open Access DOI
Dr. Rajaram Samant*
Dr. Rajaram Samant1*, Dr. Ab. Samad2
1,2Department of Medical Affairs Celagenex Research India (Pvt) Limited, India
*Correspondence to: Dr. Rajaram Samant
Fulltext PDFAims: To evaluate efficacy and safety of Inosine Monophosphate, Agmatine Sulphate, And L-Carnosine (Nurewire®) therapy for the management of spinal cord injury to standard rehabilitation protocol in patients with SCI undergoing rehabilitation.
Methods: An open-label study of 255 patients with registration of the total SCIM and of the four subscales. Clinical significance was calculated per several distribution-based approaches. The calculated clinical significance was compared with improvements by the patients to determine the percentage of patients who achieved significant improvement. The total study population was divided into two groups namely group 1 (n=127) receiving standard care and group 2 (n=128) receiving Nurewire® along with standard protocol.
Results: An improvement of at least 4 points of the total SCIM is needed to obtain a small significant improvement and 10 points to obtain a substantial improvement. Based on these results, the percentages of patients who achieved an improvement in Group 1 varied from 71% to 79% as compared to group 2 who achieved improvement varied from 91% to 94%, which is statistically significant.
Conclusion: The Nurewire® trial evaluated a novel oral combination therapy for spinal cord injuries (SCI), showing significant improvements in functional independence when administered alongside standard treatment and rehabilitation. Patients receiving Nurewire® demonstrated notable enhancements in self-care and mobility with a favorable safety profile compared to standard treatment alone. These findings indicate promising benefits for SCI patients, necessitating further research to validate long-term efficacy and underlying mechanisms.
Nurewire®; Inosine Monophosphate; Agmatine Sulphate, L-Carnosine; SCI
Rajaram Samant, Ab Samad. Efficacy and Safety of Inosine Monophosphate, Agmatine Sulphate and L-Carnosine (NUREWIRE®) Therapy for The Management of Spinal Cord Injury. Int Clinc Med Case Rep Jour. 2024;3(5):1-9.