International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 10 | Research Article | Open Access DOI
Dipanshu Kumar*
Dipanshu Kumar*, Vijendra Kumar Suman, Inzamamul Haque, Shafi Ahmad, Amrita Bharti, Kaihkashan Zabin, Anuj Naman, Nidhi Arya
Sarjug Dental College and Hospital, Darbhanga
*Correspondence to: Dipanshu Kumar
Fulltext PDFBackground: Oral submucous fibrosis is considered as a chronic debilitating condition with potential for malignant transformation. Squamous cell carcinoma arising from a background of oral submucous fibrosis presents clinically as a distinct clinical disorder due to different etiopathogenesis.
Aim: To assess the transformation of OSMF into OSCC
Methodology: This prospective case series describes sixty cases of oral squamous cell carcinoma (OSCC) that developed alongside oral submucous fibrosis (OSF). Patient clinical data were recorded that included type and duration of habits, location of tumor, size, histological grading and nodal status.
Results: A total of 78% patients were found in males and 22% in females. A total of 74.4% patients had a history of use of gutka of which 16.1% used only arecanut or gutka while the remaining used gutka along with smoking and quid habits and 26.8% cases smoked tobacco products or used smokeless tobacco. Primary site of presentation was buccal mucosa and seven cases of carcinoma at retromolar trigone (RMT) altogether accounting for 66.1% of the cases. 53.4% cases reported were advanced tumour T4 lesions, 10.1% T3 lesion, 30.1% reported as T2 lesions and 6.8% T1 lesion. 55% of cases showed nodal involvement of different level and 46.6% cases were N0. About 60.1% of cases were histologically well differentiated squamous cell carcinoma.
Conclusion: Carcinoma arising from a background of oral submucous fibrosis follows a distinct clinical presentation. Malignant transformation occurs in younger age group and with better histological grading. Overall malignant transformation of OSMF to OSCC was 12.24%.
Clinical presentation; Malignant transformation; Oral submucous fibrosis; Squamous cell carcinoma
Dipanshu Kumar, Vijendra Kumar Suman, Inzamamul Haque, Shafi Ahmad, Amrita Bharti, Kaihkashan Zabin, et al. Evaluation of Malignant Transformation of Oral Submucous Fibrosis into Oral Squamous Cell Carcinoma: A Prospective study. Int Clinc Med Case Rep Jour. 2025;4(10):1-8.