International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 2 | Case Report | Open Access DOI
Mónica Patricia Ceballos Pérez*
Fadia Yamel Abdala Mendoza2, Mónica Patricia Ceballos Pérez1*, Anakaren Monreal Reséndiz2, Sandra Liliana Aguillón Treviño2, Eduardo Díaz de León Cano3, Circe Ancona Castro1
1Dermatology Resident, Hospital Monterrey Regional Hospital ISSSTE, Monterrey, Nuevo León, México
2Pediatrics Resident, Hospital Monterrey Regional Hospital ISSSTE, Monterrey, Nuevo León, México
3Pediatrics, Hospital Monterrey Regional Hospital ISSSTE, Monterrey, Nuevo León, México
*Correspondence to: Mónica Patricia Ceballos Pérez
Fulltext PDFKawasaki disease (KD) is a systemic vasculitis that affects small and medium-sized vessels, most observed in infants and young children. Although its etiology remains unclear, recent studies suggest that infectious agents and immune dysfunction play a role in its pathogenesis. On the other hand, the atopic triad is associated with immune dysregulation and a hyperreactive immune system. This study aims to investigate the potential relationship between KD and the atopic triad, as children with a history of combined allergic diseases appear to have a higher risk of developing KD.
We present the case of a 2-year-old male patient recently diagnosed with atopic dermatitis (AD), who presented with periorbital edema, periungual desquamation of the hands and feet, fever, rhinorrhea, strawberry tongue, abdominal pain, and bilateral conjunctival injection. A presumptive diagnosis of incomplete KD was made, accompanied by a concomitant exacerbation of his AD during the same episode. Treatment was initiated with intravenous immunoglobulin (IVIG), acetylsalicylic acid, syndet cleansers, and emollients.
A genetic predisposition to the atopic triad may be associated with increased immunological susceptibility to KD, as these patients are more prone to hyperreactivity in response to infections or antigens that come into contact with the skin and mucous membranes. Studies have shown that patients with KD exhibit higher levels of eosinophils, Th2 cytokines (such as IL-4), and eosinophilic cationic protein, all of which are significantly reduced following treatment with intravenous immunoglobulin (IVIG).
Atopic dermatitis; Kawasaki disease; Atopic triad; Exacerbation of dermatitis
Fadia Yamel Abdala Mendoza, Mónica Patricia Ceballos Pérez, Anakaren Monreal Reséndiz, Sandra Liliana Aguillón Treviño, Eduardo Díaz de León Cano, Circe Ancona Castro. Exacerbation of Atopic Dermatitis Secondary to Kawasaki Disease. Int Clinc Med Case Rep Jour. 2025;4(2):1-6.