International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 2, Issue 6 | Research Article | Open Access
Department of Pharmaceutics, SIMS College of Pharmacy, India
*Correspondence to: Jasmine SKFulltext PDF
The average particle size of microspheres, which are discrete spherical particles, ranges between 1 and 1000 m. Preparation of Atorvastatin Gastro Retentive Mucoadhesive microspheres by ionic gelation technique, using various polymers [Sodium alginate, HPMC K100M, Sodium CMC, Ethyl cellulose, Methyl cellulose, Guar gum, Xanthan gum and Carbopol 940]. Promotes mucoadhesive formulations orally primarily aims to solve the stability problem with intestinal fluid and considerably increase the amount of time a medication spends in the GI tract.
In sustained drug delivery, mucoadhesive microsphere carrier systems be composed of biodegradable polymers are used. A significant impact has been made recently in the formulation and development of innovative drug delivery systems by dosage forms that can exact control the release rates and target medications to a specific body region. However, the success of these microspheres is limited owing to their short residence time at the site of absorption. This can be done by creating microspheres with bio adhesive properties and connecting them to microspheres. Oral medication delivery is significantly improved by the use of polymers that stick to the mucin epithelial surface. Both biodegradable and non-biodegradable polymer microspheres have been investigated for sustained release. The degradation products of polymers must not be harmful in order for them to function correctly because they may eventually enter the bloodstream or result in tissue implantation. The microspheres exhibited good Gastro Retentive properties for optimized formulation (F10) in the in vitro wash off test. The muco-adhesive microspheres' gradual, up to 8-hour atorvastatin release was dependent on the coat's makeup. Diffusion control and Higuchi kinetics were used to regulate drug release. Thus, these gastro-retentive microspheres are appropriate for atorvastatin's oral controlled release. In the improved formulation, The FTIR studies ruled out the drug-polymer interaction in the optimized formulation (F10). The SEM results have shown the Size and Surface Morphology of the Atorvastatin Gastro Retentive Microspheres.
Gastro retentive microspheres; Atorvastatin; Polymers; Ionic gelation technique; Oral drug delivery; FTIR studies; SEM studies
Lakshmi Savithri S, Thangabalan B, Jasmine SK, Upendra M, Bala Murali Krishna V, et al. Formulation, Optimization and Characeterization of Gastro Retentive Microspheres of Atorvastatin.Int Clinc Med Case Rep Jour. 2023;2(6):1-29.