International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 5, Issue 6 | Case Report | Open Access DOI
Tommaso Recchioni*
Benedetta Musarò1, Tommaso Recchioni1*, Marco Valerio Mariani1, Cristina Chimenti1, Andrea Corrao2, Gioacchino Galardo2, Fabio Miraldi3 and Carlo Lavalle1
1Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy
2Emergency Medicine Unit, Department of Emergency-Acceptance, Critical Areas and Trauma, University of Rome Sapienza and Azienda Ospedaliero Universitaria Policlinico Umberto I, 00161 Rome, Italy
3Department of Cardiac Surgery, University "La Sapienza" of Rome, Rome 00185, Italy
*Correspondence to: Tommaso Recchioni
Fulltext PDFAtrioventricular reciprocating tachyarrhythmias represent a constant challenge for emergency physicians, accounting for nearly 30% of arrhythmias observed in the emergency department [1]. In hemodynamically stable patients, the 2019 European Society of Cardiology (ESC) Guidelines recommend the use of vagal maneuvers followed, in case of failure, by intravenous administration of incremental boluses of adenosine (6 mg
- 12 mg) [2].
From a pharmacodynamic perspective, adenosine is described as an endogenous nucleoside derived from Adenosine Triphosphate (ATP) acting primarily through activation of A1 receptors, widely expressed in the nodal conduction system (sinoatrial node - SAN- and atrioventricular node -AVN-). Interaction with these receptors leads to an abrupt reduction of the If current through cAMP depletion and an increase in potassium conductance, resulting in hyperpolarization of nodal cells generating negative chronotropic and dromotropic effects [3]. These properties explain its high efficacy in terminating Paroxysmal Supraventricular Tachycardia (PSVT).
Benedetta Musarò, Tommaso Recchioni, Marco Valerio Mariani, Cristina Chimenti, Andrea Corrao, Gioacchino Galardo, et al. From Therapy to Trigger: Adenosine-Induced Polymorphic Ventricular Tachycardia During Treatment of Supraventricular Tachycardia. Int Clinc Med Case Rep Jour. 2026;5(6):1-7.