International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 2, Issue 15 | Case Report | Open Access DOI

Hepatocellular Carcinoma due to Hemochromatosis in a Young Patient- A Diagnosis Dilemma

Sandip Raj Pradhan^*

Shashank Bhattarai1, Sandip Raj Pradhan2*, Ranjan Kunwar3, Fahim Ahasan Al Rashid2

1Department of Internal Medicine, Guthrie Robert Packer Hospital, Pennsylvania, US

2Department of General Medicine, Hulhumale Hospital, Huvandhumaa Hingun, Maldives

3Department of Emergency and Trauma, Care and Cure Hospital Pvt. Ltd, Kapilbastu, Nepal

^*Correspondence to: Sandip Raj Pradhan 

Abstract

Hemochromatosis causes excess iron deposits in multiple organs, leading to various clinical manifestations. C282Y and H63D are the most common mutation. Diagnosing hemochromatosis is based on clinical characteristics, biochemical abnormalities, radiological findings, and genetic testing with liver biopsy. The literature review also showed 13 cases of developed HCC without cirrhosis in hemochromatosis patients. The increased risk of HCC is associated with excess iron deposition that promotes oxidative DNA damage and increases free radical activity. The amount and duration of iron overload are directly proportional to the risk of development of cirrhosis and HCC.

Keywords:

Hepatocellular carcinoma; Hemochromatosis; H63D; C282Y; Liver cancer

Citation:

Shashank Bhattarai, Sandip Raj Pradhan, Ranjan Kunwar, Fahim Ahasan Al Rashid. Hepatocellular Carcinoma due to Hemochromatosis in a Young Patient- A Diagnosis Dilemma. Int Clinc Med Case Rep Jour. 2023;2(15):1-6.