International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 6 | Research Article | Open Access DOI
Sinem Bahar Celebi*
Specialist of Anaesthesiology and Reanimation, Istanbul, Turkey
*Correspondence to: Sinem Bahar Celebi
Fulltext PDFMalignant hyperthermia (MH) is a rare but a terminal autosomal dominant myopathy that generally develops through inhalation anesthetics and/or depolarizing neuromuscular blocking agents. It has been associated with 70% ryanodine receptor gene mutation. MH crisis is as a result of malfunction in intracellular calcium mechanism, which is due to muscle rigidity and increasing in body temperature (1oC / 5 min.) that may advances to dissemine intravascular coagulation disorder (DIC), and its incidence is 1:14000-200000. MH is seen more common in men than women, and half of the reported cases consist of pediatric patients[1] . In this phenomenon 17-year-old female patient with congenital heart disease is presented, and while anesthesia was maintaining with sevoflurane during her permanent cardiac pacemaker installation operation, MH crisis was suspected. Since lack of dantrolene in our center, we could not give dantrolene to the patient, however thanks to the early and sufficient supportive care, she was discharged without remaining of any sequel. Although the patient was operated under general anesthesia before, it is noteworthy that the MH crisis has not been mentioned at patient’s anamnesis.
SinemBaharCelebi, Specialist of Anaesthesiology and Reanimation, Istanbul, Turkey. IntClinc Med Case Rep Jour. 2024; 3 (6):1-7.