International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 5 | Research Article | Open Access DOI
Rajo Païdia RADINASOA*
Solohery Jean Noel Ratsimbazafy1, Armel Mamihaja Andrianiaina2, Rajo Païdia Radinasoa2*, Hervéat Ramanandafy2, Sylvain Nainanirina2, Rova Malala Fandresena Randrianarisoa2, Marie Ida Rahatamalala3 and Hanta Marie Danielle Vololontiana2
1Department of Internal Medicine, Soavinandriana Hospital, Madagascar
2Department of Internal Medicine, Joseph Raseta Befelatanana University Hospital, Madagascar
3Department of Internal Medicine, Anosiala University Hospital, Madagascar
*Correspondence to: Rajo Païdia RADINASOA
Fulltext PDFSystemic lupus erythematosus is a potentially life-threatening autoimmune disease. The aim of this study was to describe the epidemiology-clinical profile and identify the causes of death of lupus patients in Antananarivo University Hospital.
This was a retrospective descriptive and analytical study from January 2010 to January 2021, including all lupus patients who died during hospitalisation.
During this period, 32 deaths were recorded, with an estimated mortality rate of 17.77%. The mean age of the patients was 41.18 years. The sex ratio was 0.14. Dermatological, rheumatological and renal disorders accounted for 96.8%, 75.0% and 71.9% of patients respectively. ESR and CRP were elevated in 68.7% and 59.4% of patients respectively. Antinuclear antibody and anti-native DNA antibody were positive in 71.8% and 62.5% respectively. Lupus cases were mainly attributable to complications of disease evolvement (46.8%) and infectious events (37.5%).
Mortality in systemic lupus erythematosus remains high in emerging countries. Lupus nephropathy was one of the most common causes of death in lupus patients, followed by infectious complications. The factors associated with mortality identified in our series were: a history of arterial hypertension, tuberculosis infection, the presence of altered general condition, cardiovascular and nephrological impairment (p ≤ 0.05).
Cause of death; Systemic lupus erythematosus; Madagascar
Solohery Jean Noel Ratsimbazafy, Armel Mamihaja Andrianiaina, Rajo Païdia Radinasoa, Hervéat Ramanandafy, Sylvain Nainanirina, Rova Malala Fandresena Randrianarisoa, et al. Mortality in Systemic Lupus Erythematosus seen in Antananarivo University Hospitals. Int ClincMed Case Rep Jour. 2024;3(5):1-4.