International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 1 | Case Report | Open Access DOI
Salome Satya Vani P*
Salome Satya Vani P1*, Shirisha Vodnala2, Deepthi Kadangi3, Mohammed Zabeer Uddin4, Nikitha Chidurala5, Sathwika Vudugula6
1Chitkara University, Chitkara College of Pharmacy, Rajpura-140401, Punjab, India
2, 3, 5, 6Sri Venkateshwara College of Pharmacy, Madhapur-86, Hitech city road, Hyderabad, Telangana, India
4Sri Venkateshwara College of Pharmacy, Madhapur-86, Hitech city road, Hyderabad, Telangana, India
*Correspondence to: Salome Satya Vani P
Fulltext PDFStevens-Johnson Syndrome (SJS) a type IV mediated hypersensitivity reaction, it is a rare life- threatening dermatological condition, mucocutaneous reaction often triggered by medications. It affects oral mucosa, skin, eyes, and genitals. Nitrofurantoin, an antibiotic commonly used for urinary tract infections, has been implicated as a potential cause of SJS, though it remains a rare and underreported side effect. Nitrofurantoin-induced Stevens-Johnson Syndrome, although uncommon, should be considered in the differential diagnosis of any patient presenting with acute mucocutaneous symptoms following antibiotic therapy. Early intervention and prompt discontinuation of the offending agent are critical to minimize morbidity and mortality. Treatment strategies may include corticosteroids, immunoglobulins, and other immunomodulating agents but supportive care is often suggested over other therapies as it helps in improving the therapeutic outcomes. In this case, the patient was examined and treated with Cyclosporine and Corticosteroids along with supportive care.
Stevens-Johnson Syndrome, SJS, Toxic Epidermal Necrolysis, TEN, Granulysin, Nitrofurantoin, Cyclosporine
Salome Satya Vani P, Shirisha Vodnala, Deepthi Kadangi, Mohammed Zabeer Uddin, Nikitha Chidurala, Sathwika Vudugula. Nitrofurantoin Induced Stevens-Johnson Syndrome: A Rare But Serious Adverse Reaction. Int Clinc Med Case Rep Jour. 2025;4(1):1-7.