Jolien P de Boer*
Residency Gynaecology at University Medical Centre Groningen, NetherlandsFulltext PDF
Background:Next-Generation Sequencing (NGS) is a relatively unknown diagnostic technique. The applications and clinical value of NGS in detecting pathogens is growing and the technique is superior to conventional culture. It is capable to detect bacteria at very low DNA levels (high sensitivity), has a very high specificity, it can detect mixed infections and fastidious micro-organisms.
Cases:In this article we present two women with tubo-ovarian abscesses and NGS helped guide antibiotic treatment indirectly. Although NGS did not provide information on antimicrobial susceptibility of the individual bacterial strains, identification of micro-organisms predicted antimicrobial sensitivity based on average epidemiology.
Conclusion: The advantage of this technique is that antibiotics can be used more specifically. As a result, there is less resistance, side effects, costs and better outcomes.
Microbiology; Pathogens; Tubo-ovarian abscesses
Jolien P de Boer, Janna M Munster, Gunnar I Andriesse. Novel Techniques in Microbiology to Discover Unsuspected Microbes Causing Tubo-Ovarian Abscesses. Int Clinc Med Case Rep Jour. 2023;2(11):1-5.