International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 2, Issue 14 | Case Report | Open Access
Sandip Raj Pradhan*
Hulhumale Hospital, Huvandhumaa Hingun, Maldives
*Correspondence to: Sandip Raj Pradhan
Fulltext PDFIntroduction: Acute liver injury occurs due to various causes like drugs, an autoimmune condition, and ischemia. However, Idiosyncratic, drug-induced liver injury is the second most common cause of acute liver failure after paracetamol. This may be due to an increasing trend of self-medication for different purposes or easy accessibility as an over-the-counter supplement.
Case Report: A 21-year-old male presented with yellowish discoloration of the skin and generalized itching in the body. The laboratory parameter revealed a cholestatic pattern of the liver profile. Hence, excluding the likely causes of acute liver injury, the oral androgenic supplement RAD140 was found to be the primary culprit.
Discussion: Androgenic supplement mainly includes endogenous testosterone and its synthetic derivatives. It affects the liver causing hepatotoxicity ranging from adenoma, hepatocellular carcinoma, cholestasis, and peliosis hepatis. Histologically, steroid-associated cholestasis is characterized by bile accumulation in the canaliculi but without evidence of inflammation or necrosis. RAD140 is a selective androgen receptor modulator with more inclined anabolic effects on the body and often lacks androgenic side effects.
Conclusion: Oral testosterone supplement possesses positive and negative aspects in one's health. These over-the-counter supplements should be used with special precaution as they may cause various adverse effects.
Androgenic supplement; Liver injury; Hepatotoxicity; RAD140; Cholestasis
Shashank Bhattarai, Sandip Raj Pradhan.Oral Androgenic Supplement RAD140 Induced Acute Liver Injury- A Case Report. Int Clinc Med Case Rep Jour. 2023;2(14):1-5.