International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 2, Issue 14 | Case Report | Open Access
Metwali H*
Pharm D, Internal Medicine Clinical Pharmacist, Pharmaceutical Care Department at King Abdullah International Medical Research Center / King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City –Jeddah Saudi Arabia
Fulltext PDFHydroxychloroquine (HCQ) is approved for treatment of malaria and rheumatic diseases such as systemic lupus erythematous (SLE), rheumatoid arthritis, Q-fever and juvenile idiopathic arthritis. HCQ consider to be safe medication with narrow safety margin. Cardiovascular and cerebrovascular effects may result as from HCQ overdose. It is often fatal due to cardiovascular toxicity. We present a case for a young female who survived after HCQ intoxication with discussion about the possible recommendation for management. The cardiovascular complications were the main symptoms of toxicity that resulted in cardiac failure with atrio-ventricular block, ventricular arrhythmias torsade de points and QT- interval prolongation. The main goal of HCQ intoxication treatment is to prevent the hemodynamic complications. Treatment recommendations are established based on limited clinical experience. The main effective treatment consists of epinephrine, diazepam and mechanical ventilation. Close clinical monitoring and early recognition of toxicity symptoms and immediate withdrawal of HCQ is important approach in management of HCQ toxicity and it is essential for reversibility of cardiomyopathy. In conclusion, HCQ toxicity is not commonly seen in clinical practice, the reported cases in the literature are few. It is considered fatal as it leads to cardiac complications, therefore, effective therapy is important to stabilize the heart functions and minimize the severe complications.
Case Report; Hydroxychloroquine; Aminoquinoline; HCQ toxicity; Cardiovascular toxicity
Hasan H, Moudi M, Aseeri M, Metwali H. Pharmacological Management after Administration of High-Dose Aminoquinoline: Case Report. Int Clinc Med Case Rep Jour.2023;2(14):1-6.