International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 11 | Research Article | Open Access
Wenli Chen*
Department of General Surgery, The Afffliated Bozhou Hospital of Anhui Medical University, China
*Correspondence to: Wenli Chen
Fulltext PDFBackground: Appendicitis is an acute inflammatory disorder involving dysregulated PI3K/Akt signaling and intestinal barrier damage, and phosphatase and tensin homolog (PTEN)—a key negative regulator of PI3K/Akt—modulates inflammation and epithelial repair.
Objective: To synthesize basic experimental evidence on PTEN’s role in appendicitis and explore nursing relevance.
Methods: Retrospective analysis of PubMed (2019–2024) using keywords “Appendicitis[MeSH] AND PTEN[MeSH] AND Basic Research[Filter]”. Eligible studies were animal/cell models focusing on PTEN in appendicitis.
Results: Ten studies were included. PTEN expression was downregulated in appendiceal tissues of animal models (mouse/rat) and LPS-stimulated cells, correlating with activated PI3K/Akt, elevated pro-inflammatory cytokines (TNF-α, IL-6), and epithelial apoptosis. PTEN activation/overexpression alleviated inflammation and barrier damage.
Conclusion: PTEN is a critical anti-inflammatory/repair mediator in appendicitis, providing a basis for nursing strategies in inflammation control and infection prevention.
Appendicitis; Phosphatase; Inflammation control; Epithelial repair
Chen W. Phosphatase and Tensin Homolog (PTEN) in Appendicitis. Int Clinc Med Case Rep Jour. 2025;4(11):1-5.