International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 11 | Research Article | Open Access
Wenli Chen*
Department of General Surgery, The Afffliated Bozhou Hospital of Anhui Medical University, China
*Correspondence to: Wenli Chen
Fulltext PDFBackground: Appendicitis is an acute inflammatory disorder driven by dysregulated cyclic nucleotide signaling, and phosphodiesterases (PDEs)—key cyclic nucleotide hydrolyases—regulate inflammation, vascular function, and intestinal barrier repair.
Objective: To synthesize basic experimental evidence on PDEs’ role in appendicitis and explore nursing relevance.
Methods: Retrospective analysis of PubMed (2019–2024) using keywords “Appendicitis[MeSH] AND Phosphodiesterases[MeSH] AND Basic Research[Filter]”. Eligible studies were animal/cell models focusing on PDEs in appendicitis.
Results: Ten studies were included. PDE4/PDE5 (dominant subtypes) expression was upregulated in appendiceal tissues of animal models (mouse/rat) and LPS-stimulated immune/epithelial cells, correlating with increased pro-inflammatory cytokines. PDE inhibition alleviated appendiceal inflammation and barrier damage.
Conclusion: PDEs (PDE4/PDE5) promote inflammatory progression in appendicitis, providing a basis for nursing strategies in inflammation control and infection prevention.
Appendicitis; Acute inflammatory disorder; Inflammation control; Vascular function
Chen W. Phosphodiesterases (PDEs) inRetrospective Analysis of Basic Experimental Studies. Int Clinc Med Case Rep Jour. 2025;4(11):1-5.