International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 6 | Case Report | Open Access

Physical Compatibility of Cefazolin and Select Crystalloid Intravenous Fluids

Gabriella Baki*

Department of Pharmacy Practice, University of Toledo, College of Pharmacy and Pharmaceutical Sciences, USA

*Correspondence to: Gabriella Baki 

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Abstract

Background: Patient care may necessitate concomitant administration of cefazolin with intravenous (IV) fluids. Data is limited for cefazolin with 0.45% sodium chloride (NaCl) and Lactated Ringer’s (LR). Objective: To determine the physical compatibility of cefazolin with 0.45% NaCl and LR admixtures over 24 hours. Methods: Cefazolin 20 mg/mL admixtures were prepared in a 1:1 ratio with 0.45% NaCl or LR and examined at baseline, 1, 5, 8, and 24 hours. A demonstrable change was an alteration in visual appearance, absorbance (> 0.010 units), and pH (> 0.1 unit). Results: Visual and absorbance assessments found no demonstrable changes for the admixtures. Both admixtures had demonstrable pH changes at hour 24. The average readings for 0.45% NaCl admixture did not have demonstrable changes until the 24-hour reading. Conclusions: The 0.45% NaCl and LR admixtures were physically compatible for up to 8 hours. Further studies may be warranted to determine their chemical stability.

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Citation:

Sophia A. Carroll, Gabriella Baki, Mariann D. Churchwell, Mitchell S. Howard. Physical Compatibility of Cefazolin and Select Crystalloid Intravenous Fluids. Int Clinc Med Case Rep Jour. 2025;4(6):1-5.