International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 6 | Case Report | Open Access
Sophia A. Carroll, Gabriella Baki*, Mariann D. Churchwell, Mitchell S. Howard*
Department of Pharmacy Practice, University of Toledo, College of Pharmacy and Pharmaceutical Sciences, USA
*Correspondence to: Sophia A. Carroll, Gabriella Baki*, Mariann D. Churchwell, Mitchell S. Howard
Fulltext PDFBackground: Patient care may necessitate concomitant administration of cefazolin with intravenous (IV) fluids. Data is limited for cefazolin with 0.45% sodium chloride (NaCl) and Lactated Ringer’s (LR). Objective: To determine the physical compatibility of cefazolin with 0.45% NaCl and LR admixtures over 24 hours. Methods: Cefazolin 20 mg/mL admixtures were prepared in a 1:1 ratio with 0.45% NaCl or LR and examined at baseline, 1, 5, 8, and 24 hours. A demonstrable change was an alteration in visual appearance, absorbance (> 0.010 units), and pH (> 0.1 unit). Results: Visual and absorbance assessments found no demonstrable changes for the admixtures. Both admixtures had demonstrable pH changes at hour 24. The average readings for 0.45% NaCl admixture did not have demonstrable changes until the 24-hour reading. Conclusions: The 0.45% NaCl and LR admixtures were physically compatible for up to 8 hours. Further studies may be warranted to determine their chemical stability.
Sophia A. Carroll, Gabriella Baki, Mariann D. Churchwell, Mitchell S. Howard. Physical Compatibility of Cefazolin and Select Crystalloid Intravenous Fluids. Int Clinc Med Case Rep Jour. 2025;4(6):1-5.