International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 2, Issue 4 | Research Article | Open Access
Shaobo Wu*
Health Science Center, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, PR China
Fulltext PDFPPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene. This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. However, the relationship between PPARG expression, tumor immunity, and prognosis in Breast invasive carcinoma (BRCA) remain unclear. PPARG expression and its influence on tumor prognosis were analyzed by the ONCOMINE, Tumor Immune Estimation Resource (TIMER) and Kaplan-Meier plotter. The relationship between BRCA expression and tumor immunity were analyzed by TIMER and Gene Expression Profiling Interactive Analysis (GEPIA). PPARG expression in BRCA tissues correlated with prognosis. PPARG expression was significantly lower in several human cancers, including HCC, than in corresponding nor mal tissues. Moreover, we screened hub genes by constructing a protein‐protein interaction (PPI) network. These findings demonstrate that PPARG is a potential prognostic biomarker that determines cancer progression and correlated with tumor immune cells infiltration in BRCA.
PPARG; Biomarker; Immune infiltrates; Breast cancer
Yaohui Jiang, Xiaoyu Zhou, Yalin Jv, Yuxin Ma,Yujiao Dong, Shaobo Wu. PPARG: A New Prognostic Biomarker and Correlates with Immune Infiltrates in Breast Invasive Carcinoma Based on Bioinformatics Analysis. Int Clinc Med Case Rep Jour. 2023;2(4):1-15.