International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 2, Issue 17 | Research Article | Open Access DOI

Prevalence and Association of Primary Hypothyroidism with Metabolic Syndrome: A 1- Year Cross-Sectional Study

Ganavi Y P*

Ganavi Y P1* and Naveen S Angadi2

1Assistant Professor, Department of Endocrinology, Ramaiah Medical college, Bangalore, India

2Professor, Department of General Medicine, Jawaharlal Nehru Medical College, Belgaum, India

*Correspondence to: Ganavi Y P 

Fulltext PDF


Background: Hypothyroidism and metabolic syndrome are associated with an abnormal lipid profile and impaired cardiac and endocrine functions. The coexistence of these two conditions may have a higher clinical impact on cardiovascular morbidity and mortality.

Aim:To study the prevalence and association of primary hypothyroidism in patients with metabolic syndrome.

Materials and Methods:This cross-sectional study was conducted from January 2013 to December 2013 in 117 patients with metabolic syndrome. Patients fulfilling the inclusion criteria were enrolled through simple random sampling and divided into euthyroid and hypothyroid groups based on thyroid profile. Patients were investigated for thyroid and lipid profiles, blood pressure, and glycemic levels. Data were analyzed using SPSS 20 and compared using the Chi-square test, and the p-value of p</=0.05 was considered statistically significant.

Results: Out of 117 patients, 29 (24.79%) showed hypothyroidism, of which 21 (72.41%) were women. Overt hypothyroidism was observed in 11 (37.93%) patients and subclinical hypothyroidism was observed in 18 (62.07%) patients. Systolic and diastolic blood pressure was higher in hypothyroid patients compared to euthyroid patients. Fasting blood glucose levels >/=100 mg/dL and cholesterol levels>/=200 mg/dL were higher in the hypothyroid group. A significant association was observed between hypothyroidism and gender (p = 0.005). 

Conclusion:An abnormal increase in lipid and glycemic levels and blood pressure was observed in hypothyroid patients with metabolic syndrome. No significant association was found between hypothyroidism and components of metabolic syndrome.


Hypothyroidism; Metabolic syndrome; Dyslipidemia; Hypertension and Dysglycemia


Ganavi Y P, Naveen S Angadi. Prevalence and Association of Primary Hypothyroidism with Metabolic Syndrome: A 1- Year Cross-Sectional Study Int Clinc Med Case Rep Jour.2023;2(17):1-9.