International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 5, Issue 3 | Case Report | Open Access DOI

Primary Bone Lymphoma: A Case Report

Corazon A Ngelangel*

Corazon A Ngelangel1,3*, Donnel AT Rubio2,3, Thomas Jason A Ngelangel3, Kaye Angeli H Gonzales-So1, Jennifer Sandoval-Tan1

1Division of Medical Oncology, Department of Medicine, University of the Philippines-College of Medicine Philippine General Hospital

2Department of Orthopedic Surgery - Philippine General Hospital, Philippines

3Asian Cancer Institute – Asian Hospital and Medical Center, Philippines

*Correspondence to: Corazon A Ngelangel 

Fulltext PDF

Abstract

A 26-year-old woman presented with three months progressive right hip pain and difficult ambulation, which was subsequently diagnosed as germinal center–type diffuse large B-cell lymphoma in the right femoral head, neck and upper-midshaft region without any nodal or visceral lesions. Primary bone lymphoma (PBL) is an uncommon extranodal lymphoma representing approximately 1% of all lymphomas and 3–7% of malignant primary bone tumors. While it typically affects older adults, occurrences in younger patients are rare and may lead to delayed recognition. PBL may radiologically resemble benign bone disease, emphasizing the importance of clinical suspicion. Diagnosis requires multimodal evaluation, with chemoimmunotherapy remaining the primary treatment.

Keywords:

Primary bone lymphoma; Case report

Citation:

Corazon A Ngelangel, Donnel AT Rubio, Thomas Jason A Ngelangel, Kaye Angeli H Gonzales-So, Jennifer Sandoval-Tan. Primary Bone Lymphoma: A Case Report. Int Clinc Med Case Rep Jour. 2026;5(3):1-8.