International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 11 | Case Report | Open Access
Amol Amonkar*
Jude Rodrigues1, Amita Rohilla2, Saavi Ranjan2, Yash Caroicar2, Amol Amonkar1*
1Professor and Head-Department of General Surgery, Goa Medical College and Hospital, Goa, India
2Goa Medical College and Hospital, Goa, India
*Correspondence to: Amol Amonkar
Fulltext PDFPrimary neuroendocrine carcinoma of the breast is a distinct subtype, first recognized by the World Health Organization (WHO) in 2003 [1]. In 2012, the WHO revised the category renaming it as Breast Carcinoma With Neuroendocrine Features (BCNF) [2]. However, in 2019 WHO classification recommended defining the tumours with invasive breast carcinoma having nonspecific and specific morphology types (mucinous carcinoma, solid papillary carcinoma, etc) and non-uniform neuroendocrine morphology and neuroendocrine marker expression as “Invasive carcinoma of the breast with neuroendocrine differentiation” [3]. These tumours are exceedingly rare and under-recognized subtype of breast carcinoma representing only 2-5 % of all invasive breast cancer. We hereby report a case diagnosed as invasive ductal carcinoma with neuroendocrine differentiation in a 60-year old female patient who presented with a painless left breast lump.
Breast carcinoma; Invasive; Ductal carcinoma; Neuroendocrine differentiation
Jude Rodrigues, Amita Rohilla, Saavi Ranjan, Yash Caroicar, Amol Amonkar. Primary Breast Carcinoma with Neuroendocrine Differentiation: A Rare and Challenging Entity. Int Clinc Med Case Rep Jour. 2025;4(11):1-4.