International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 4, Issue 11 | Research Article | Open Access
Wenli Chen*
Department of General Surgery, The Afffliated Bozhou Hospital of Anhui Medical University, China
*Correspondence to: Wenli Chen
Fulltext PDFBackground: Appendicitis is an acute inflammatory disorder involving dysregulated cell signaling and intestinal barrier damage, and protein kinase C (PKC)—a key serine/threonine kinase—regulates inflammation, epithelial apoptosis, and barrier integrity.
Objective: To synthesize basic experimental evidence on PKC’s role in appendicitis and explore nursing relevance.
Methods: Retrospective analysis of PubMed (2019–2024) using keywords “Appendicitis[MeSH] AND Protein Kinase C[MeSH] AND Basic Research[Filter]”. Eligible studies were animal/cell models focusing on PKC in appendicitis.
Results: Ten studies were included. PKCα/PKCβ (dominant subtypes) activation (phosphorylation) was upregulated in appendiceal tissues of animal models (mouse/rat) and LPS-stimulated immune/epithelial cells, correlating with increased pro-inflammatory cytokines and epithelial apoptosis. PKC inhibition alleviated appendiceal inflammation and barrier damage.
Conclusion: PKC (PKCα/PKCβ) promotes inflammatory progression in appendicitis, providing a basis for nursing strategies in inflammation control and infection prevention.
Appendicitis; Retrospective analysis; Cytokines; Epithelial apoptosis
Chen W. Protein Kinase C (PKC) Analysis of Basic Experimental Studies. Int Clinc Med Case Rep Jour. 2025;4(11):1-5.