International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 5 | Research Article | Open Access DOI
Sadia Iram*
Sidra Ahmad1, Sumaira Nawaz2, Maryam Iftikhar3, Sadia Iram4*, Syed Abdullah Haider5 and Aden Ghani6 1General Surgery Senior Registrar Al Nafees Hospital/Isra University, Pakistan
2General Surgery Senior Registrar Shifa International Hospital, Pakistan
3General Surgery Senior Registrar Pakistan Railway Hospital, Pakistan
4Final year MBBS student at Lahore Medical and Dental College, Pakistan
5Final Year MBBS student at University College of Medicine and Dentistry, Pakistan
6Final year MBBS student at Akhtar Saeed Medical and Dental College, Pakistan
*Correspondence to: Sadia Iram
Fulltext PDFBackground: Although laparoscopic cholecystectomy is a common and widely accepted technique, the use of prophylactic antibiotics in elective laparoscopic cholecystectomy remains controversial. This study aimed to find out the efficacy of antibiotic prophylaxis in preventing postoperative infective complications in low-risk elective laparoscopic cholecystectomy patients.
Objective: The objective of this study was to compare the frequency of postoperative SSI in patients receiving prophylactic antibiotics and those not receiving prophylactic antibiotics, with the aim of evaluating the effectiveness of antibiotic administration in reducing the incidence of surgical site infections (SSIs) following various surgical procedures.
Material and methods: We conducted a randomized controlled trial over six months involving 218 patients undergoing laparoscopic cholecystectomy (LC) in the surgical unit-1 of the Holy Family Hospital in Rawalpindi, Pakistan. The patients were randomly placed into two categories: Group A and Group B. Group A was given prophylactic antibiotic 1 gram of ceftriaxone and Group B was given 0.9% normal saline 5 ml (placebo) thirty minutes before surgery. Postoperative surgical site infections were recorded as per operational definition on the day 7, 14, and 28 days follow-up after surgery.
Results: The frequency and percentage of post-operative surgical site infection in patients receiving prophylactic antibiotics and without prophylactic antibiotics after elective laparoscopic cholecystectomy was 9 (8.3%) and 2 (1.8%) respectively, which is statistically significant (p-value 0.030).
Conclusion: The study concludes that prophylactic antibiotics are not necessarily preventive in low-risk patients and should be avoided.
Cholelithiasis, Surgical Site Infection, Prophylactic Antibiotics, Laparoscopic Cholecystectomy
Ahmad S, Nawaz S, Iftikhar M, Iram S, Haider SA, Ghani A. Role of Prophylactic Antibiotics on Surgical Site Infection in Elective Laparoscopic Cholecystectomy: A Randomized Control Trial. Int Clinc Med Case Rep Jour. 2024;3(5):1-8.