International Clinical and Medical Case Reports Journal (ISSN: 2832-5788) | Volume 3, Issue 6 | Research Article | Open Access DOI
Sesto Cabral Maria Eugenia*
Sesto Cabral Maria Eugenia*, González Exequiel
Laboratorio de Estudios Farmacéuticos y Biotecnología Farmacéutica (LEFyBiFa)-Instituto de Biotecnología Farmacéutica y Alimentaria (INBIOFAL) - CONICET-UNT - Tucumán, Argentina
*Correspondence to: Sesto Cabral Maria Eugenia
Fulltext PDFScalp psoriasis is an inflammatory dermatosis whereit causes redness, peeling and swelling and givestheperson a sensationofitching and/or pain. It is a more common disease tan we may think. Hair makes the scalp difficult to treat and the adjacent facial skin is particularly sensitive to topical treatments. A metadata study carried out in 2016 reveals that the main treatments are those that involve the combination of vitamin D with corticosteroids for the treatmen tof the inflammatory process. The difficulty in applying creams and lotions for the treatment of scalp psoriasis led us to design a product for hair from the first instance. In this frame work we developed a vehicle treatment in the form of a shampoo. For this design we use bacterial nano cellulose as an ingredient in the formula, facilitating there placemen to firritating agents in comercial shampoo. BNC has distinctive characteristics mainly due to its size and fibrillar arrangement. BNC introduces modifications in its behavior as a biomaterial, its biological and physicochemical properties. Two plantex tracts with recognized pro-healing and anti-inflammatory activity were used as active ingredients Matricaria chamomilla and Calendula officinalis.
The objective of this work was to design a low ormedium detergent action shampoo with natural ingredients for the anti-inflammatory and pro-healing adjuvant treatment of scalp psoriasis. Using the properties of BNC were place irritating excipients such as sodium lauryl sulfate and NaCl. The designed product was tested pharmaco-technologically according to what is indicated in the Argentine Pharmacopoeia VII edition. Tests on healthy volunteers were carriedout to determine the functionality of the designed natural shampoo. The tests on volunteers with scalp psoriasis were carriedout to prove, ease of application of treatments, absence of irritation, reduction of inflammation and attenuation of symptoms.
The designed product isuse ful for the adjuvant treatment of scalp sebopsoriasis. The pharmaceutical form of choice, is a good vehicle for topical administration of the natural active ingredients. The ingredients of the formula were added in the properproportions to ensure conform it yboth therapeutically and aesthetically required by the panel so volunteers. Prototypetested by healthy volunteers achieved the máximum levels of conformity by the user. The designed natural shampoo proved its therapeutic effectiveness in a panel of 9 volunteers diagnosed with cebo psoriasis. The formula is suitable for daily use in a permanent way in patients with scalp psoriasis. None of the patients reported occurrence of local irritation, skin pain, folliculitis, typical side effects of conventional reatment. Although more studies are necessary in volunteers with psoriasis, this natural, biodegradable and effective formula would allow the dose of corticosteroids to be reduced, reducing the side effects of the conventional treatment used.
Bacterial nano cellulose; Scalp psoriasis; Topical formulation; Nanobiotecnology; Shampoo
Sesto Cabral Maria Eugenia, González Exequiel. Scalp Psoriasis Natural Treatment. Shampoo Based on Bacterial Nanocellulose. Design, Technological studies and Concept Tests. Int Clinc Med Case Rep Jour. 2024;3(6):1-15.